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KMID : 0043320040270121207
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Archives of Pharmacal Research
2004 Volume.27 No. 12 p.1207 ~ p.1210
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Antidiabetic Coumarin and Cyclitol Compounds from Peucedanum japonicum
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Lee Sung-Ok
Choi Sang-Zin
Lee Jong-Hwa
Chung Sung-Hyun
Park Sang-Hyun
Kang Hee-Chol
Yang Eun-Young
Cho Hi-Jae
Lee Kang-Ro
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Abstract
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The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O- -D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).
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KEYWORD
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Peucedanum japonicum, Umbelliferae, Coumarin, Inositol
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